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The age-related decline in neuromodulator levels, combined with the lack of significant learning and memory effects from PXN LOW in aged animals (though a trend was noted, P = 0.07), may explain the reduced cognitive benefits of both caffeine and paraxanthine in older individuals

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17.11 (ae) Schwannoma at the flexor surface of the left lower leg in a 41-year-old woman: (a) US shows a sharply defined, homogeneously hyporeflective tumor with a fusiform shape and an entering and exiting nerve (tail sign)